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Insulin degludec (By injection)

Insulin Degludec (IN-su-lin de-GLOO-dek)

Treats diabetes.

Brand Name(s):

Tresiba

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to insulin degludec.

How to Use This Medicine:

Injectable

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin.
  • Your healthcare provider will work with you to personalize your dose and treatment based on your insulin needs and lifestyle. You will be taught how to give yourself the injections. Make sure you understand all instructions. Ask your doctor if you have questions.
  • Always double-check both the concentration (strength) of your insulin and your dose. Concentration and dose are not the same. The dose is how many units of insulin you will use. The concentration tells how many units of insulin are in each milliliter (mL), such as 100 units/mL (U-100), but this does not mean you will use 100 units at a time.
  • If you use insulin once a day, it is best to use it at about the same time every day.
  • Check the liquid inside the pen or vial. It should be clear and colorless. Do not use the medicine if it looks thick, cloudy, or discolored, or if it has particles in it. Do not mix this medicine with any other insulin or with water.
  • You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas.
  • Use a new needle and syringe each time you inject your medicine.
  • Always check the label before use, to make sure you have the correct type of insulin. Do not change the brand, type, or concentration unless your doctor tells you to.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Make sure that there are at least 8 hours between doses. Do not take extra medicine to make up for a missed dose.
  • Unopened medicine: You may store the pen or vial in the refrigerator until its expiration date or at room temperature for up to 56 days. Protect from light. Do not freeze. Do not use the medicine if it has been frozen.
  • Opened medicine: You may store the pen or vial in the refrigerator or at room temperature, away from direct heat and light. Throw the pen or vial away after 56 days, even if there is still insulin in it.
  • Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can change the amount of insulin you need to use and make it harder for you to control your diabetes. Tell your doctor about all other medicines that you are using.
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, or heart failure.
  • This medicine may cause the following problems:
    • Low blood sugar or low potassium levels in the blood
    • Fluid retention or heart failure (when used together with a thiazolidinedione [TZD] medicine)
  • Never share insulin pens or needles with anyone. Sharing these can pass hepatitis viruses, HIV, or other illnesses from one person to another.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Dry mouth, increased thirst, muscle cramps, nausea, vomiting, uneven heartbeat
  • Rapid weight gain, swelling in your hands, ankles, or feet, chest pain, trouble breathing, tiredness
  • Shaking, trembling, sweating, fast or pounding heartbeat, lightheadedness, hunger, confusion

If you notice these less serious side effects, talk with your doctor:

  • Redness, pain, itching, swelling, or skin changes where the shot was given

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 8/2/2019
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