Health Guide

Aliskiren/hydrochlorothiazide (By mouth)

Aliskiren (a-lis-KYE-ren), Hydrochlorothiazide (hye-droe-klor-oh-THYE-a-zide)

Treats high blood pressure. This medicine contains a thiazide diuretic (water pill).

Brand Name(s):

Tekturna HCT

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use if you had an allergic reaction to aliskiren, hydrochlorothiazide, or a sulfa drug, or if you are pregnant.

How to Use This Medicine:


  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Take this medicine the same way and at the same time every day. Take it routinely with or without food. Do not take with a high-fat meal.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use this medicine if you have diabetes and also take another blood pressure medicine (ACE inhibitor or ARB). Do not use this medicine together with cyclosporine or itraconazole.
  • Some foods and medicines affect how aliskiren/hydrochlorothiazide works. Tell your doctor if you are using cholestyramine, colestipol, cyclophosphamide, lithium, methotrexate, another diuretic (water pill, such as furosemide), insulin or an oral diabetes medicine, or an NSAID pain or arthritis medicine (such as aspirin, diclofenac, ibuprofen, naproxen, celecoxib).
  • Ask your doctor before you use any medicine, supplement, or salt substitute that contains potassium.

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Tell your doctor if you are breastfeeding, or if you have kidney problems, liver disease, heart or blood vessel disease (including heart failure or a history of a heart attack), diabetes, glaucoma, gout, high cholesterol levels, low blood pressure, lupus, trouble urinating, or a history of asthma or allergies.
  • This medicine may cause the following problems:
    • Kidney problems
    • Vision problems or glaucoma
  • This medicine could lower your blood pressure too much when you first use it or if you are dehydrated. Stand or sit up slowly if you are dizzy.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Change in how much or how often you urinate
  • Confusion, weakness, uneven heartbeat, trouble breathing, or numbness or tingling in your hands, feet, or lips
  • Joint pain
  • Lightheadedness, dizziness, or fainting
  • Trouble seeing, eye pain
  • Rapid weight gain, swelling in your hands, ankles, or feet

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 8/2/2019
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