Health Guide

Deflazacort (By mouth)

Deflazacort (dee-FLAYZ-a-kort)

Treats Duchenne muscular dystrophy. This medicine is a corticosteroid.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to deflazacort or you have a fungal infection.

How to Use This Medicine:

Suspension, Tablet

  • Your doctor will tell you how much medicine to use. Do not use more than directed.
  • Tablet: Swallow whole, or crush it and mix with applesauce which to be taken immediately.
  • Suspension: Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Throw away any unused oral suspension 1 month after the bottle is opened for the first time.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some foods and medicines can affect how deflazacort works. Tell your doctor if you are using any of the following:
    • Clarithromycin, diltiazem, efavirenz, fluconazole, phenytoin, rifampin, or verapamil
    • Insulin or diabetes medicine
    • Muscle relaxer
  • Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
  • This medicine may interfere with vaccines. Ask your doctor before you get a flu shot or any other vaccines.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease (including hepatitis B), amebiasis, blood clotting problems, congestive heart failure, diabetes, high blood pressure, depression or mental health problems, digestive problems (including ulcers, ulcerative colitis, or diverticulitis), myasthenia gravis, osteoporosis, pheochromocytoma (adrenal tumor), thyroid problems, tuberculosis, or a recent heart attack.
  • This medicine may cause the following problems:
    • Increase risk of stomach or bowel perforation
    • Unusual mood or behavior
    • Cataracts or glaucoma
    • Serious skin reactions
    • Slow growth in children
  • This medicine may cause you to get infections more easily. Tell your doctor if you have any type of infection before you start treatment. Avoid people who are sick or have infections. If you are exposed to chickenpox or measles, tell your doctor right away.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Bloody, black, tarry stools, vomiting of material that looks like coffee grounds, severe stomach pain
  • Bone, joint, or muscle pain
  • Color changes on the skin, dark freckles, easy bruising, muscle weakness, round puffy face
  • Depression, mood swings, trouble sleeping, unusual thoughts, feelings, or behavior
  • Dry mouth, increased thirst, muscle cramps, nausea or vomiting, uneven heartbeat
  • Eye pain, vision changes
  • Fast, slow, or pounding heartbeat
  • Fever, chills, cough, sore throat, body aches
  • Numbness or weakness in your arm or leg, or on one side of your body, sudden or severe headache, problems with vision, speech, or walking

If you notice these less serious side effects, talk with your doctor:

  • Increased appetite

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 7/4/2018
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