Health Guide

Silodosin (By mouth)

Silodosin (sil-oh-DOE-sin)

Treats problems caused by an enlarged prostate (benign prostatic hyperplasia, or BPH). This medicine is an alpha-blocker.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to silodosin, or if you are also using clarithromycin (Biaxin®), itraconazole (Sporanox®), ketoconazole (Nizoral®), or ritonavir (Norvir®). Do not use this medicine if you have severe kidney disease or severe liver disease.

How to Use This Medicine:


  • Your doctor will tell you how much medicine to use. Do not use more than directed.
  • It is best to take this medicine with food or milk.
  • If you have trouble swallowing the capsule, you may open the capsule and pour the medicine into a small amount of cool or room temperature applesauce. Stir this mixture well and swallow it right away (within 5 minutes) without chewing. Then drink a glass of cool water to make sure you swallow all of the medicine.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using medicine for high blood pressure, such as diltiazem, doxazosin, terazosin, verapamil, Cardura®, Hytrin®. Tell your doctor if you are also using cyclosporine (such as Gengraf®, Neoral®, Sandimmune®), erythromycin (Ery-Tab®), or medicine to treat impotence (such as sildenafil, tadalafil, vardenafil, Cialis®, Levitra®, Viagra®).

Warnings While Using This Medicine:

  • Make sure your doctor knows if you have kidney disease, liver disease, low blood pressure, or a history of prostate cancer.
  • This medicine may make you dizzy or lightheaded. Avoid driving, using machines, or doing anything else that could be dangerous until you know how this medicine affects you. Stand or sit up slowly if you feel dizzy, so you do not faint.
  • Make sure your eye doctor knows you are using this medicine if you have cataract surgery. This medicine may cause intraoperative floppy iris syndrome (IFIS), which could complicate the surgery. This may happen even after you stop using this medicine.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Lightheadedness, dizziness, or fainting when getting up suddenly from a lying or sitting position

If you notice these less serious side effects, talk with your doctor:

  • Sexual problems

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 7/4/2018
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