Health Guide

Morphine sulfate liposome (By injection)

Morphine Sulfate Liposome (MOR-feen SUL-fate LYE-poh-some)

Treats pain after surgery. This medicine is a narcotic analgesic.

Brand Name(s):

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not receive this medicine if you have had an allergic reaction to morphine or to related narcotic pain-killers. You should not receive this medicine if you have severe asthma (or during an asthma attack), lung disease, blocked intestines, or a head injury. You should not receive this medicine for labor pains during child birth.

How to Use This Medicine:


  • Your doctor will prescribe your exact dose and how often it should be given. This medicine will be given through a catheter (small tube) into the fluid around your spinal cord.
  • A nurse or other health provider will give you this medicine.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.
  • Tell your doctor if you have used an MAO inhibitor such as Eldepryl®, Marplan®, Nardil®, or Parnate® within the last 14 days. Make sure your doctor knows if you are using a blood thinner such as warfarin (Coumadin®).
  • There are many medicines that can interact with morphine. Make sure your doctor knows about all other medicines you are using.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breast feeding.
  • Make sure your doctor knows if you have heart disease, low blood pressure, liver disease, pancreatic disease, lung disease, kidney disease, problems urinating, gall bladder disease, an enlarged prostate, or seizures.
  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chest pain or trouble breathing.
  • Fast or slow heartbeat.
  • Fever or chills.
  • Lightheadedness or fainting.
  • Numbness or tingling in your hands and feet.
  • Seizures.
  • Severe vomiting or stomach pain.
  • Trouble urinating, or a decrease in how much or how often you urinate.
  • Weakness or tiredness, pale skin, or pale lip color.

If you notice these less serious side effects, talk with your doctor:

  • Anxiety, dizziness, or headache.
  • Back pain, muscle pain, sweating.
  • Constipation or mild stomach pain.
  • Dry mouth, increased thirst, or muscle cramps.
  • Mild nausea or vomiting.
  • Pain, itching, swelling, burning, or a lump under your skin at the site of injection.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 7/4/2018
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