Health Guide

Isosulfan blue (By injection)

Isosulfan Blue (eye-soe-SUL-fan BLOO)

Used during a medical test or imaging procedure to help organs or other body parts show up better.

Brand Name(s):

Isosulfan Blue Novaplus, Lymphazurin, PremierPro Rx Isosulfan Blue

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. You should not receive it if you had an allergic reaction to isosulfan blue or triphenylmethane.

How to Use This Medicine:


  • A health caregiver will give you this medicine. It is given as a shot under your skin.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, if you had an allergic reaction to any dye or medicine given during a test or procedure, or if you have a history of asthma or allergies.
  • This medicine may cause your urine to turn blue for up to 24 hours after you receive it. Talk to your doctor if you have any questions.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Confusion, dizziness, lightheadedness, skin rash, sweating
  • Pain, swelling, itching, blistering, rash, or a lump under your skin where the shot was given

If you notice these less serious side effects, talk with your doctor:

  • Blue discoloration of the skin

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 7/4/2018
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