Health Guide

Methscopolamine (By mouth)

Methscopolamine (meth-skoe-POL-a-meen)

Treats symptoms of peptic ulcer (wearing away of the lining of the stomach or small intestine).

Brand Name(s):

Pamine, Pamine Forte

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to methscopolamine (Pamine®), or if you have glaucoma (increased pressure in your eyes). You should not use this medicine if you have intestinal problems (intestinal atony, pyloroduodenal stenosis) or bowel blockage (paralytic ileus), or if you have blockage of your urine flow (obstructive uropathy). You should not use this medicine if you have severe ulcerative colitis or toxic megacolon, or if you have myasthenia gravis.

How to Use This Medicine:


  • Your doctor will tell you how much medicine to use. Do not use more than directed.
  • You should take this medicine ½ hour (30 minutes) before your meals and again at bedtime, unless your doctor tells you differently.

If a dose is missed:

  • If you miss a dose or forget to take your medicine, call your doctor or pharmacist for instructions.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using other medicines with anticholinergic effects. These medicines include tricyclic antidepressants, such as amitriptyline (Elavil®), doxepin (Sinequan®), nortriptyline (Aventyl®, Pamelor®), and antipsychotics, such as chlorpromazine (Thorazine®), clozapine (Clozaril®), or quetiapine (Seroquel®).
  • Make sure your doctor knows if you are also using an antacid medicine, such as aluminum carbonate, magnesium hydroxide, Basalgel®, Gaviscon®, Maalox®, Pepcid®, Pepto-Bismol®, Rolaids®, or Tums®.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breast feeding, or if you have liver or kidney problems. Make sure your doctor knows if you have ulcerative colitis, or if you have autonomic neuropathy (damage to the autonomic nerves).
  • Make sure your doctor knows if you have hyperthyroidism (overactive thyroid gland), or if you have coronary heart disease. Make sure your doctor knows if you have a very fast heart beat, or if you have high blood pressure. Make sure your doctor knows if you have an enlarged prostate.
  • Make sure your doctor knows if you have ever had problems with or intolerance to anticholinergic medicines. Anticholinergic medicines include antihistamines and tricyclic antidepressants.
  • Avoid spending more time in very hot places. Because this medicine can cause you to sweat less than normal, the heat can make you sick.
  • This medicine may make you drowsy or dizzy. Avoid driving, using machines, or doing anything else that may be dangerous if you are not alert.
  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
  • Call your doctor if your symptoms do not improve or if they get worse.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

If you notice these less serious side effects, talk with your doctor:

  • Blurred vision.
  • Breast feeding women: Making less milk.
  • Decrease in how much or how often you urinate.
  • Decrease in the amount of sweat.
  • Dry mouth.
  • Fast or uneven heart beat.
  • Feeling unusually nervous, or confused.
  • Headache.
  • Loss of your sense of taste.
  • Men: Problems having or keeping an erection.
  • Nausea, vomiting, constipation, or feeling bloated.
  • Skin rash or redness, or hives.
  • Unable to sleep.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 7/4/2018
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