Health Guide

Hydroxyzine (By injection)

Hydroxyzine (hye-DROX-i-zeen)

Treats anxiety, tension, and agitation. Also treats nausea and vomiting.

Brand Name(s):

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

The medicine is not right for everyone. You should not receive it if you had an allergic reaction to hydroxyzine. Do not use this medicine during early pregnancy.

How to Use This Medicine:


  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into one of your muscles.
  • A nurse or other health provider will give you this medicine.
  • Your doctor may change your dose to the oral form of this medicine if you need ongoing treatment.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some drugs and foods can affect how hydroxyzine works. Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

Warnings While Using This Medicine:

  • This drug may not be safe to use during early pregnancy. However, it may be used during labor.
  • This medicine may make you drowsy. Do not drive a car or doing anything else that could be dangerous until you are alert.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Drowsiness that does not go away
  • Swelling, blisters, color changes, or other skin or tissue damage where the injection was given

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 7/4/2018
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