Because tests called the free T4 blood test and TBG blood tests are now available, the T3RU test is rarely used these days.
Resin T3 uptake; T3 resin uptake; Thyroid hormone-binding ratio
How the Test is Performed
A blood sample is needed.
How to Prepare for the Test
Your provider will tell you if you need to stop taking any medicines before the test that may affect your test result. DO NOT stop taking any medicine without first talking to your provider.
Some drugs that can increase T3RU levels include:
- Anabolic steroids
- Salicylates (high dose)
Some drugs that can decrease T3RU levels include:
- Antithyroid medicines
- Birth control pills
Pregnancy can also decrease T3RU levels.
These things can increase thyroxin binding globulin (TBG) levels (see below section "Why the Test is Performed" for more about TBG):
- Male hormones (androgens)
- Serious illness
- Kidney disease
Other medicines that bind to protein in the blood can also affect test results
How the Test will Feel
When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon goes away.
Why the Test is Performed
This test is done to check your thyroid function. Thyroid function depends on the action of many different hormones, including thyroid-stimulating hormone (TSH), T3, and T4.
This test helps check the amount of T3 that thyroxin binding globulin (TBG) is able to bind. TBG is a protein that carries most of the T3 and T4 in the blood.
Your provider may recommend a T3RU test if you have signs of a thyroid disorder, including:
- Hyperthyroidism (overactive thyroid)
- Hypothyroidism (underactive thyroid)
- Thyrotoxic periodic paralysis (muscle weakness caused by high levels of thyroid hormone in the blood)
Normal values range from 24% to 37%.
Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your provider about the meaning of your specific test results.
What Abnormal Results Mean
Higher-than-normal levels may indicate:
Lower-than-normal levels may indicate:
Abnormal results may also be due to an inherited condition of high TBG levels. Usually thyroid function is normal in people with this condition.
This test may also be done for:
- Chronic thyroiditis (swelling or inflammation of the thyroid gland, including Hashimoto disease)
- Drug-induced hypothyroidism
- Graves disease
- Subacute thyroiditis
- Thyrotoxic periodic paralysis
- Toxic nodular goiter
There is little risk involved with having your blood taken.Veins and arteries vary in size from one person to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.
Other risks associated with having blood drawn are slight, but may include:
- Excessive bleeding
- Fainting or feeling lightheaded
- Multiple punctures to locate veins
- Hematoma (blood buildup under the skin)
- Infection (a slight risk any time the skin is broken)
Guber HA, Farag AF. Evaluation of endocrine function. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 23rd ed. St Louis, MO: Elsevier; 2017:chap 24.
Salvatore D, Davies TF, Schlumberger MJ, Hay ID, Larsen PR. Thyroid physiology and diagnostic evaluation of patients with thyroid disorders. In: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, eds. Williams Textbook of Endocrinology. 13th ed. Philadelphia, PA: Elsevier; 2016:chap 11.
Weiss RE, Refetoff S. Thyroid function testing. In: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Adult and Pediatric. 7th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 78.
Reviewed By: Brent Wisse, MD, Associate Professor of Medicine, Division of Metabolism, Endocrinology & Nutrition, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.