Cryptococcosis is infection with the fungi Cryptococcus neoformans and Cryptococcus gattii.
C. neoformans var. neoformans infection; C. neoformans var. gatti infection; C. neoformans var. grubii infection
C neoformans and C gattii are the fungi that cause this disease. Infection with C neoformans is seen worldwide. Infection with C gattii has mainly been seen in the Pacific Northwest region of the United States, British Columbia in Canada, Southeast Asia, and Australia. Cryptococcus is the most common fungus that causes serious infection.
Both types of fungi are found in soil. If you breathe the fungus in, it infects your lungs. The infection may go away on its own, remain in the lungs only, or spread throughout the body (disseminate). Cryptococcosis is most often seen in people with a weak immune system, such as those who:
- Are infected with HIV/AIDS
- Take high doses of corticosteroid medicines
- Are on chemotherapy medicines for cancer
- Have Hodgkin disease
- Have had an organ transplant
C gattii may affect people with normal immune system.
C neoformans is the most common life-threatening cause of fungal infection in people with HIV/AIDS.
People between 20 to 40 years of age have this infection.
The infection may spread to the brain in people who have a weakened immune system. Neurological (brain) symptoms start slowly. Most people have swelling and irritation of the brain and spinal cord when they are diagnosed. Symptoms of brain infection may include:
The infection can also affect the lungs and other organs. Lung symptoms may include:
- Difficulty in breathing
- Chest pain
Other symptoms may include:
- Bone pain or tenderness of the breastbone
- Skin rash, including pinpoint red spots (petechiae), ulcers, or other skin lesions
- Sweating -- unusual, excessive at night
- Swollen glands
- Unintentional weight loss
People with a healthy immune system may have no symptoms at all.
Exams and Tests
The health care provider will perform a physical exam and ask about symptoms and travel history. The physical exam may reveal:
- Abnormal breath sounds
- Fast heart rate
- Mental status changes
- Stiff neck
Tests that may be done include:
- Blood culture to differentiate between the two fungi
- CT scan of the head
- Sputum culture and stain
- Lung biopsy
- Bronchoscopy and bronchoalveolar lavage
- Spinal tap to obtain a sample of cerebrospinal fluid (CSF)
- Cerebrospinal fluid (CSF) culture and other tests to check for signs of infection
- Chest x-ray
- Cryptococcal antigen test (looks for a certain molecule that is shed from the cell wall of the Cryptococcus neoformans fungus into the bloodstream or CSF)
Some infections require no treatment. Even so, there should be regular checkups for a full year to make sure the infection has not spread. If there are lung lesions or the disease spreads, your provider will prescribe you antifungal medicines. These medicines may need to be taken for a long time.
- Amphotericin B (can have severe side effects)
Central nervous system involvement often causes death or leads to permanent damage.
When to Contact a Medical Professional
Call your provider if you develop symptoms of cryptococcosis, especially if you have a weakened immune system.
Kauffman CA. Cryptococcosis. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 336.
Perfect JR. Cryptococcosis (Cryptococcus neoformans and Cryptococcus gattii). In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, Updated Edition. 8th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 264.
Robles WS, Ameen M. Cryptococcosis. In: Lebwohl MG, Heymann WR, Berth-Jones J, Coulson IH, eds. Treatment of Skin Disease: Comprehensive Therapeutic Strategies. 5th ed. Philadelphia, PA: Elsevier; 2018:chap 49.
Reviewed By: Jatin M. Vyas, MD, PhD, Assistant Professor in Medicine, Harvard Medical School; Assistant in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.