Addison disease is a disorder that occurs when the adrenal glands do not produce enough hormones.
Adrenocortical hypofunction; Chronic adrenocortical insufficiency; Primary adrenal insufficiency
The adrenal glands are small hormone-releasing organs located on top of each kidney. They are made up of an outer portion, called the cortex, and an inner portion, called the medulla.
The cortex produces 3 hormones:
- Glucocorticoid hormones (such as cortisol) maintain sugar (glucose) control, decrease (suppress) immune response, and help the body respond to stress.
- Mineralocorticoid hormones (such as aldosterone) regulate sodium and potassium balance.
- Sex hormones, androgens (male) and estrogens (female), affect sexual development and sex drive.
Addison disease results from damage to the adrenal cortex. The damage causes the cortex to produce hormone levels that are too low.
This damage may be caused by the following:
- The immune system mistakenly attacking the adrenal glands (autoimmune disease)
- Infections such as tuberculosis, HIV, or fungal infections
- Hemorrhage into the adrenal glands
Risk factors for the autoimmune type of Addison disease include other autoimmune diseases:
- Swelling (inflammation) of the thyroid gland that often results in reduced thyroid function (chronic thyroiditis)
- Thyroid gland produces too much thyroid hormone (overactive thyroid, Graves disease)
- Itchy rash with bumps and blisters (dermatitis herpetiformis)
- Parathyroid glands in the neck do not produce enough parathyroid hormone (hypoparathyroidism)
- Pituitary gland does not produce normal amounts of some or all of its hormones (hypopituitarism)
- Autoimmune disorder that affects the nerves and the muscles they control (myasthenia gravis)
- Body does not have enough healthy red blood cells (pernicious anemia)
- Testicles cannot produce sperm or male hormones (testicular failure)
- Type I diabetes
- Loss of brown color (pigment) from areas of the skin (vitiligo)
Certain rare genetic defects may also cause adrenal insufficiency.
Symptoms of Addison disease include:
- Chronic diarrhea, nausea, and vomiting
- Darkening of the skin in some places
- Dizziness when standing up
- Low-grade fever
- Extreme weakness, fatigue, and slow, sluggish movement
- Darker skin on the inside of the cheeks and lips (buccal mucosa)
- Salt craving (eating food with a lot of added salt)
- Weight loss with reduced appetite
Exams and Tests
The health care provider will perform a physical exam and ask about the symptoms.
Blood tests will likely be ordered and may show:
- Increased potassium
- Low blood pressure, especially with a change in body position
- Low cortisol level
- Low sodium level
- Low pH
- Normal testosterone and estrogen levels, but low DHEA level
- High eosinophil count
Additional laboratory tests may be ordered.
Other tests may include:
Treatment with replacement corticosteroids and mineralocorticoids will control the symptoms of this disease. These medicines usually need to be taken for life.
Never skip doses of your medicine for this condition because life-threatening reactions may occur.
Your provider may tell you to increase your dosage for a short time because of:
During an extreme form of adrenal insufficiency, called adrenal crisis, you must inject hydrocortisone right away. Treatment for low blood pressure is usually needed as well.
Some people with Addison disease are taught to give themselves an emergency injection of hydrocortisone during stressful situations. Always carry medical ID (card, bracelet, or necklace) that says you have adrenal insufficiency. The ID should also say the type of medicine and dosage you need in case of an emergency.
With hormone therapy, many people with Addison disease are able to lead a nearly normal life.
Complications can occur if you take too little or too much adrenal hormone.
Complications also may result from the following related illnesses:
- Chronic thyroiditis
- Ovarian hypofunction or testicular failure
- Pernicious anemia
- Overactive thyroid
When to Contact a Medical Professional
Call your provider if:
- You are unable to keep your medicine down due to vomiting.
- You have stress such as infection, injury, trauma, or dehydration. You may need to have your medicine adjusted.
- Your weight increases over time.
- Your ankles begin to swell.
- You develop new symptoms.
- On treatment, you develop signs of a disorder called Cushing syndrome
If you have symptoms of adrenal crisis, give yourself an emergency injection of your prescribed medicine. If it is not available, go to the nearest emergency room or call 911.
Symptoms of adrenal crisis include:
- Abdominal pain
- Difficulty breathing
- Dizziness or lightheadedness
- Low blood pressure
- Reduced level of consciousness
Barthel A, Willenberg HS, Gruber M, Bornstein SR. Adrenal insufficiency. In: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Adult and Pediatric. 7th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 102.
Napier C, Pearce SH. Current and emerging therapies for Addison's disease. Curr Opin Endocrinol Diabetes Obes. 2014;21(3):147-153. PMID: 24755997 www.ncbi.nlm.nih.gov/pubmed/24755997.
Nieman LK. Adrenal cortex. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 227.
Reviewed By: Brent Wisse, MD, Associate Professor of Medicine, Division of Metabolism, Endocrinology & Nutrition, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.